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Article

Bromodeoxyuridine labelling as an alternative method to identify 6-thioguanine-resistant mutant lymphocytes in humans.

Mutation research - 17 Dec 1999

Maffei F, Vigagni F, Norppa H, Hrelia P

Abstract excerpt

6-Thioguanine-resistant (TGR) mutant lymphocytes in human blood are usually enumerated by the cloning assay which allows the molecular characterisation of the HPRT mutations to be detected. A "short-term" alternative approach is provided by the anti-bromodeoxyuridine (anti-BrdU) technique in which TGR lymphocytes are identified immunocytochemically by their ability to synthesise DNA in the presence of...

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Identifiers

PMID: 10635989
DOI: 10.1016/s0027-5107(99)00165-7

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