Article
Screening E-cadherin germline mutations in Italian patients with familial diffuse gastric cancer: an analysis in the District of Urbino, Region Marche, Central Italy.
Tumori - 1 Jan 2000
Graziano Francesco, Ruzzo Anna Maria, Bearzi Italo, Testa Enrica, Lai Vittorio, Magnani Mauro
Abstract excerpt
AIMS & BACKGROUND: Hereditary diffuse gastric cancer is a recently defined cancer syndrome caused by inactivating, heterozygous germline mutations in the E-cadherin gene (CDH1). To date, 16 truncating germline CDH1 mutations have been described in hereditary diffuse gastric cancer families in different ethnic groups, but so far, no investigation has been addressed to Italian patients. In the District of Urbino,...
Topics
- Adult
- Cadherins
- Female
- Genetic Predisposition to Disease
- Genetic Testing
- Germ-Line Mutation
- Humans
- Male
- Middle Aged
- Pedigree
- Stomach Neoplasms