Hereditary diffuse gastric cancer and E-cadherin: description of the first germline mutation in an Italian family.

doi:10.1016/j.ejso.2006.10.028

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Article

Hereditary diffuse gastric cancer and E-cadherin: description of the first germline mutation in an Italian family.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology - 1 May 2007

Roviello F, Corso G, Pedrazzani C, Marrelli D, De Falco G, Berardi A, Garosi L, Suriano G, Vindigni C, De Stefano A, Leoncini L, Seruca R, Pinto E

Abstract excerpt

AIMS: Germline mutation of the E-cadherin gene (CDH1) accounts for the Hereditary Diffuse Gastric Cancer (HDGC) syndrome. Fourteen pedigrees with Diffuse Gastric Cancer that fulfilled the International Gastric Cancer Linkage Consortium (IGCLC) criteria were selected and screened for CDH1 germline...

Topics

Cadherins
DNA, Neoplasm
Female
Genetic Predisposition to Disease
Germ-Line Mutation
Humans
Immunohistochemistry
Italy
Male
Pedigree
Polymerase Chain Reaction
Retrospective Studies
Stomach Neoplasms

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Source

Open in PubMed

Identifiers

PMID: 17126523
DOI: 10.1016/j.ejso.2006.10.028

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-17126523-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.