Article
Low expression of E-Cadherin and CDH1 variants associated with diffuse gastric cancer.
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion - 20 Feb 2023
García-Ruvalcaba Azaria, Vázquez-Ibarra Katia C, Magaña-Torres María T, Rizo de-la-Torre Lourdes Del C, Meléndez-Aranda Lennon, López-Armas Gabriela, Cruz-Ramos José A, Peregrina-Sandoval Jorge, Espinoza-Jiménez Esther, Rosales-Gradilla María E, Sánchez-López Josefina Y
Abstract excerpt
Background: Reduced or null expression of E-cadherin protein is a frequent cause of diffuse gastric cancer (DGC). More than 50% of patients with DGC present somatic variants in CDH1 gene. Objectives: The objectives of this study were to study E-cadherin expression and identify variants in the CDH1 gene in gastric tumors of patients with DGC. Methods: We studied 18 Mexican DGC patients who attended a hospital of...
Topics
- Humans
- Antigens, CD
- Cadherins
- Genetic Predisposition to Disease
- Mexico
- Stomach Neoplasms