Article
E-cadherin alterations in hereditary disorders with emphasis on hereditary diffuse gastric cancer.
Progress in molecular biology and translational science - 1 Jan 2013
Oliveira Carla, Pinheiro Hugo, Figueiredo Joana, Seruca Raquel, Carneiro Fátima
Abstract excerpt
The only gastric cancer (GC) syndrome with a proven inherited defect is designated as hereditary diffuse gastric cancer (HDGC) and is caused by germline E-cadherin/CDH1 alterations. Other E-cadherin-associated hereditary disorders have been identified, encompassing HDGC families with or without cleft-lip/palate involvement, isolated early-onset diffuse GCs, and lobular breast cancer families without GC. To date,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.