E-cadherin alterations in hereditary disorders with emphasis on hereditary diffuse gastric cancer.

doi:10.1016/B978-0-12-394311-8.00015-7

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Article

E-cadherin alterations in hereditary disorders with emphasis on hereditary diffuse gastric cancer.

Progress in molecular biology and translational science - 1 Jan 2013

Oliveira Carla, Pinheiro Hugo, Figueiredo Joana, Seruca Raquel, Carneiro Fátima

Abstract excerpt

The only gastric cancer (GC) syndrome with a proven inherited defect is designated as hereditary diffuse gastric cancer (HDGC) and is caused by germline E-cadherin/CDH1 alterations. Other E-cadherin-associated hereditary disorders have been identified, encompassing HDGC families with or without c...

Topics

Animals
Cadherins
Disease Models, Animal
Genetic Diseases, Inborn
Genetic Predisposition to Disease
Germ-Line Mutation
Humans
Mice
Stomach Neoplasms

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