Article
Accuracy of Hereditary Diffuse Gastric Cancer Testing Criteria and Outcomes in Patients With a Germline Mutation in CDH1.
Gastroenterology - 1 Oct 2015
van der Post Rachel S, Vogelaar Ingrid P, Manders Peggy, van der Kolk Lizet E, Cats Annemieke, van Hest Liselotte P, Sijmons Rolf, Aalfs Cora M, Ausems Margreet G E M, Gómez García Encarna B, Wagner Anja, Hes Frederik J, Arts Neeltje, Mensenkamp Arjen R, van Krieken J Han, Hoogerbrugge Nicoline, Ligtenberg Marjolijn J L
Abstract excerpt
BACKGROUND & AIMS: Germline mutations in the cadherin 1, type 1, E-cadherin gene (CDH1) cause a predisposition to gastric cancer. We evaluated the ability of the internationally accepted hereditary diffuse gastric cancer (HDGC) criteria to identify individuals with pathogenic mutations in CDH1, and assessed their outcomes. The criteria were as follows: families with 2 or more cases of gastric cancer, with at...
Topics
- Adult
- Aged
- Antigens, CD
- Breast Neoplasms
- Cadherins
- Carcinoma, Lobular
- DNA Mutational Analysis
- Female
- Genetic Predisposition to Disease