Article
A novel -66T/C polymorphism in Fc epsilon RI alpha-chain promoter affecting the transcription activity: possible relationship to allergic diseases.
Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2003
Hasegawa Masanari, Nishiyama Chiharu, Nishiyama Makoto, Akizawa Yushiro, Mitsuishi Kouichi, Ito Tomonobu, Kawada Hiroshi, Furukawa Susumu, Ra Chisei, Okumura Ko, Ogawa Hideoki
Abstract excerpt
We found a novel polymorphism, -66T/C, in the promoter region of human FcepsilonRIalpha, the specific component of the high affinity receptor for IgE (FcepsilonRI), which is essential for the cell surface expression of FcepsilonRI and the binding of IgE Ab. When the effect of the single nucleotide replacement on the promoter function was analyzed, the transcription activity of the T allele promoter was found to...
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