Article
Two different transcription factors discriminate the -315C>T polymorphism of the Fc epsilon RI alpha gene: binding of Sp1 to -315C and of a high mobility group-related molecule to -315T.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2008
Kanada Shunsuke, Nakano Nobuhiro, Potaczek Daniel P, Maeda Keiko, Shimokawa Naomi, Niwa Yusuke, Fukai Tatsuo, Sanak Marek, Szczeklik Andrew, Yagita Hideo, Okumura Ko, Ogawa Hideoki, Nishiyama Chiharu
Abstract excerpt
The alpha-chain is a specific component of FcepsilonRI, which is essential for the cell surface expression of FcepsilonRI and the binding of IgE. Recently, two single nucleotide polymorphisms (SNPs) in the alpha-chain promoter, -315C>T and -66T>C, have been shown by statistic studies to associate with allergic diseases. The effect of -66 SNP on GATA-1-mediated promoter activity has been already indicated. In the...
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