Article
Polymorphisms in the Fc epsilon RI beta promoter region affecting transcription activity: a possible promoter-dependent mechanism for association between Fc epsilon RI beta and atopy.
Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2004
Nishiyama Chiharu, Akizawa Yushiro, Nishiyama Makoto, Tokura Tomoko, Kawada Hiroshi, Mitsuishi Kouichi, Hasegawa Masanari, Ito Tomonobu, Nakano Nobuhiro, Okamoto Atsushi, Takagi Atsushi, Yagita Hideo, Okumura Ko, Ogawa Hideoki
Abstract excerpt
The beta subunit of the high-affinity IgE receptor (FcepsilonRI) plays an important role in IgE-mediated allergic reactions as an amplifier for cell surface expression and signal transduction of FcepsilonRI. FcepsilonRIbeta is presumed to be one of the genes linked with atopic diseases. However, the validity of the associations previously found between single nucleotide polymorphisms (SNPs) in FcepsilonRIbeta and...
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