Article
Gene-gene interaction between interleukin-4 and interleukin-4 receptor alpha in Korean children with asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Aug 2004
Lee S-G, Kim B-S, Kim J-H, Lee S-Y, Choi S-O, Shim J-Y, Hong T-J, Hong S-J
Abstract excerpt
BACKGROUND: Interleukin-4 receptor alpha (IL-4Ralpha), which binds IL-4 and IL-13, is involved in signal transduction of those cytokines that lead to IgE production, and is also a key functional component of the Th2 lymphocyte phenotype. OBJECTIVE: To determine whether IL-4 and IL-4Ralpha polymorphisms are associated with susceptibility to asthma and whether there are gene-gene interactions between IL-4 and...
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