Article
FcepsilonRIalpha gene -18483A>C polymorphism affects transcriptional activity through YY1 binding.
Immunogenetics - 1 Sept 2009
Potaczek Daniel P, Maeda Keiko, Wang Qing-Hui, Nakano Nobuhiro, Kanada Shunsuke, Stepien Ewa, Branicka Agnieszka, Fukai Tatsuo, Hara Mutsuko, Tokura Tomoko, Ogawa Hideoki, Undas Anetta, Okumura Ko, Nishiyama Chiharu
Abstract excerpt
Three frequent genetic polymorphisms in the human high-affinity IgE receptor alpha-subunit (FcepsilonRIalpha) were shown to be associated with allergic disorders and/or total serum IgE levels in allergic patients. Two of these were previously demonstrated to affect FcepsilonRIalpha expression while the third -18483A>C (rs2494262) has not yet been subjected to functional studies. We hypothesized that the -18483A>C...
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