Article
Identifying MHC class I epitopes by predicting the TAP transport efficiency of epitope precursors.
Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2003
Peters Björn, Bulik Sascha, Tampe Robert, Van Endert Peter M, Holzhütter Hermann-Georg
Abstract excerpt
We are able to make reliable predictions of the efficiency with which peptides of arbitrary lengths will be transported by TAP. The pressure exerted by TAP on Ag presentation thus can be assessed by checking to what extent MHC class I (MHC-I)-presented epitopes can be discriminated from random peptides on the basis of predicted TAP transport efficiencies alone. Best discriminations were obtained when N-terminally...
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