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Article

Yeast recombination pathways triggered by topoisomerase II-mediated DNA breaks

30 Jul 2003

Abstract excerpt

Topoisomerase II is a ubiquitous enzyme that removes knots and tangles from the genetic material by generating transient double-strand DNA breaks. While the enzyme cannot perform its essential cellular functions without cleaving DNA, this scission activity is inherently dangerous to chromosomal integrity. In fact, etoposide and other clinically important anticancer drugs kill cells by increasing levels of...

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PMID: 12888496
DOI: 10.1093/nar/gkg497

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Source receipt: pubmed, retrieved 7 Sept 2026.

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