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Etoposide, Topoisomerase II and Cancer

17 Jun 2005

Abstract excerpt

Etoposide is an important chemotherapeutic agent that is used to treat a wide spectrum of human cancers. It has been in clinical use for more than two decades and remains one of the most highly prescribed anticancer drugs in the world. The primary cytotoxic target for etoposide is topoisomerase II. This ubiquitous enzyme regulates DNA under- and overwinding, and removes knots and tangles from the genome by...

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PMID: 16101488
DOI: 10.2174/1568011054222364

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