Article
Homologous recombination and the roles of double-strand breaks.
Trends in biochemical sciences - 1 Oct 1995
Shinohara A, Ogawa T
Abstract excerpt
Double-strand breaks (DSBs) and single-strand gaps in damaged DNA are efficiently repaired by mechanisms associated with recombination. Recombination is a series of complex biochemical reactions, requiring at least 20 gene products, even in Escherichia coli. Genes homologous to bacterial and yeast recombination genes have been cloned in higher eukaryotes, suggesting there might be a common fundamental mechanism...
Topics
- Animals
- DNA
- DNA Damage
- DNA Repair
- DNA, Single-Stranded
- DNA-Binding Proteins
- Fungal Proteins
- Humans
- Meiosis
- Mitosis
- Models, Genetic
- Mutation