Topoisomerase deficiencies subtly enhance global genomic repair of ultraviolet-induced DNA damage in Saccharomyces cerevisiae.

doi:10.1016/j.dnarep.2006.01.007

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Article

Topoisomerase deficiencies subtly enhance global genomic repair of ultraviolet-induced DNA damage in Saccharomyces cerevisiae.

DNA repair - 10 May 2006

Cline Susan D, Hanawalt Philip C

Abstract excerpt

Genetic integrity depends upon the precision of all pathways that manipulate DNA. DNA repair mechanisms prevent mutations and aberrant recombination events by removing DNA damage. DNA topoisomerases maintain favorable nucleic acid topology for replication, transcription, and chromosome segregation. However, topoisomerases can also become trapped on DNA at sites of damage, and thereby, might alter the efficiency...

Topics

DNA Damage
DNA Repair
DNA Topoisomerases
Genome, Fungal
Mutation
Pyrimidine Dimers
Saccharomyces cerevisiae
Ultraviolet Rays

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PMID: 16516562
DOI: 10.1016/j.dnarep.2006.01.007

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