The Aurora kinases: role in cell transformation and tumorigenesis.

doi:10.1023/a:1023789416385

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Article

The Aurora kinases: role in cell transformation and tumorigenesis.

Cancer metastasis reviews - 1 Dec 2003

Katayama Hiroshi, Brinkley William R, Sen Subrata

Abstract excerpt

Aurora kinases representing a novel family of serine/threonine kinases have been identified as key regulators of the mitotic cell division process. The three members of this kinase family, identified so far, referred to as Aurora-A, Aurora-B and Aurora-C kinases, are close homologues of the prototypic yeast Ipll and Drosophila aurora kinases, which are known to be involved in the regulation of centrosome...

Topics

Amino Acid Sequence
Animals
Aurora Kinase B
Aurora Kinase C
Aurora Kinases
Binding Sites
Cell Cycle
Cell Cycle Proteins
Cell Division
Cell Transformation, Neoplastic
Chromosomes
G2 Phase
Green Fluorescent Proteins
Humans
Kinetochores

Source

Open in PubMed

Identifiers

PMID: 12884918
DOI: 10.1023/a:1023789416385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Luminescent Proteins

Mitosis

Models, Biological