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Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapy

15 Jan 2021

Abstract excerpt

Aurora kinase A (AURKA) belongs to the family of serine/threonine kinases, whose activation is necessary for cell division processes via regulation of mitosis. AURKA shows significantly higher expression in cancer tissues than in normal control tissues for multiple tumor types according to the TCGA database. Activation of AURKA has been demonstrated to play an important role in a wide range of cancers, and...

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PMID: 33451333
DOI: 10.1186/s12943-020-01305-3

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