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Article

Aurora B: A new promising therapeutic target in cancer

14 Apr 2018

Abstract excerpt

A critical step for maintenance of genetic stability is chromosome segregation, which requires a high coordination of cellular processes. Loss of mitotic regulation is a possible cause of aneuploidy in human epithelial malignancy and it is thought to create an abnormal nuclear morphology in cancer cells. Serine/threonine protein kinase Aurora B gene plays a regulatory role from G2 to cytokinesis, encompassing key...

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PMID: 29862159
DOI: 10.5582/irdr.2018.01018

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