Article
Mutation analysis of CTNNB1 (beta-catenin) and AXIN1, the components of Wnt pathway, in cervical carcinomas.
Oncology reports - 1 Jan 2000
Su Tsung-Hsien, Chang Jan-Gowth, Yeh Kun-Tu, Lin Ting-Hsu, Lee Tai-Ping, Chen Jui-Chang, Lin Cheng-Chieh
Abstract excerpt
The components of the Wnt-signaling pathway are mutated in tumors, but the relationship between these components and cervical cancer has not been elucidated. In this study, we used immunohistochemistry, single strand confirmation polymorphism (SSCP) and direct sequencing methods to analyze the mutation and protein expressions of both CTNNB1 and AXIN1 in cervical cancer. Among the 30 tested cervical cancers, no...
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