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Article

AXIN2 Polymorphisms, the β-Catenin Destruction Complex Expression Profile and Breast Cancer Susceptibility.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2015

Aristizabal-Pachon Andres Felipe, Carvalho Thais Inacio, Carrara Helio Humberto, Andrade Jurandyr, Takahashi Catarina Satie

Abstract excerpt

BACKGROUND: The Wnt/β-catenin signaling pathway is an important regulator of cellular functions such as proliferation, survival and cell adhesion. Wnt/β-catenin signaling is associated with tumor initiation and progression; β-catenin mutations explain only 30% of aberrant signaling found in breast cancer, indicating that other components and/or regulation of the Wnt/β-catenin pathway may be involved. OBJECTIVE:...

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Identifiers

PMID: 26514524
DOI: 10.7314/apjcp.2015.16.16.7277

Genes

AXIN2
APC

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