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Article

Mutations of the APC, beta-catenin, and axin 1 genes and cytoplasmic accumulation of beta-catenin in oral squamous cell carcinoma.

Journal of cancer research and clinical oncology - 1 Dec 2005

Iwai Soichi, Katagiri Wataru, Kong Chie, Amekawa Shigeki, Nakazawa Mitsuhiro, Yura Yoshiaki

Abstract excerpt

PURPOSE: The Wnt pathway is involved in carcinogenesis and three regulatory genes of the Wnt pathway, APC, beta-catenin and Axin are mutated in some primary human cancers. Mutations in these genes can impair the down regulation of beta-catenin, which results in the stabilization of beta-catenin, accumulation of free beta-catenin and subsequent activation of the Wnt pathway. To clarify the genetic alterations of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Squamous Cell

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Share to Fluorescent Antibody Technique, Direct

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Share to Mouth Neoplasms

Share to Polymorphism, Single-Stranded Conformational

Source

Identifiers

PMID: 16163548
DOI: 10.1007/s00432-005-0027-y

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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