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Article

Correlation between protein expression and epigenetic and mutation changes of Wnt pathway-related genes in oral cancer.

International journal of oncology - 1 Oct 2003

Yeh Kun-Tu, Chang Jan-Gowth, Lin Ting-Hsu, Wang Yu-Fen, Chang Jan-Yi, Shih Mu-Chin, Lin Cheng-Chieh

Abstract excerpt

The components of the Wnt-signaling pathway are reported to be mutated in human cancer cells, but the relationship between the components and oral squamous carcinoma (SCC) is still unknown. In this study, we analyzed the epigenetic changes and expression patterns of four member proteins of the Wnt-signaling pathway and analyzed the mutations of beta-catenin and AXIN 1 genes, in order to explore the roles of the...

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PMID: 12963979

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APC

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