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Article

Axin, the main component of the Wnt signaling pathway, is not mutated in kidney tumors in children.

International journal of molecular medicine - 1 Apr 2002

Miao Jiangyong, Kusafuka Takeshi, Udatsu Yuko, Okada Akira

Abstract excerpt

The Wnt signaling pathway is essential for embryonic development and can be involved in tumorigenesis when aberrantly activated. In a subset of Wilms' tumors, beta-catenin mutations have been identified, and this suggested that abnormally activated Wnt signaling may contribute to tumorigenesis of this tumor. Because Axin has been recognized as a main component of Wnt signaling, and its mutations were reported in...

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PMID: 11891531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Axin, the main component of the Wnt signaling pathway, is not mutated in kidney tumors in children.PMID 11891531Read ↗

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The links between axin and carcinogenesisSemantic proximity Read ↗

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Chibby, a novel antagonist of the Wnt pathway, is not involved in Wilms tumor development.Semantic proximity Read ↗

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Mutations in AXIN2 gene as a risk factor for tooth agenesis and cancer: A review.Semantic proximity Read ↗

Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas.Semantic proximity Read ↗

Tissue-specific roles of Axin2 in the inhibition and activation of Wnt signaling in the mouse embryo.Semantic proximity Read ↗

Mutations in components of the Wnt signaling pathway in adenoid cystic carcinoma.Semantic proximity Read ↗

Mouse axin and axin2/conductin proteins are functionally equivalent in vivo.Semantic proximity Read ↗

Correlation between protein expression and epigenetic and mutation changes of Wnt pathway-related genes in oral cancer.Semantic proximity Read ↗

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