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Epigenetic and genetic analysis of WNT signaling pathway in sporadic colorectal cancer patients from Iran.

Molecular biology reports - 1 May 2012

Naghibalhossaini Fakhraddin, Zamani Mozhdeh, Mokarram Pooneh, Khalili Islam, Rasti Mozhgan, Mostafavi-Pour Zohreh

Abstract excerpt

The WNT signaling is deregulated in most human colorectal cancers (CRC). Promoter methylation has been proposed as an alternative mechanism to inactivate genes in tumors. To gain insight into the methylation silencing of the WNT pathway during colorectal carcinogenesis, we examined the aberrant methylation profile of four genes, APC, Axin1, Axin2, and GSK3β in an unselected series of 112 sporadic colorectal...

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PMID: 22207181
DOI: 10.1007/s11033-011-1434-6

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APC

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