Article
Molecular subsets of mantle cell lymphoma defined by the IGHV mutational status and SOX11 expression have distinct biologic and clinical features.
Cancer research - 15 Oct 2012
Navarro Alba, Clot Guillem, Royo Cristina, Jares Pedro, Hadzidimitriou Anastasia, Agathangelidis Andreas, Bikos Vasilis, Darzentas Nikos, Papadaki Theodora, Salaverria Itziar, Pinyol Magda, Puig Xavier, Palomero Jara, Vegliante Maria Carmela, Amador Virgina, Martinez-Trillos Alejandra, Stefancikova Lenka, Wiestner Adrian, Wilson Wyndham, Pott Christiane, Calasanz Maria Jose, Trim Nicola, Erber Wendy, Sander Birgitta, Ott German, Rosenwald Andreas, Colomer Dolors, Giné Eva, Siebert Reiner, Lopez-Guillermo Armando, Stamatopoulos Kostas, Beà Sílvia, Campo Elías
Abstract excerpt
Mantle cell lymphoma (MCL) is a heterogeneous disease with most patients following an aggressive clinical course, whereas others having an indolent behavior. We conducted an integrative and multidisciplinary analysis of 177 MCL to determine whether the immunogenetic features of the clonotypic B-cell receptors (BcR) may identify different subsets of tumors. Truly unmutated (100% identity) IGHV genes were found in...
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