Article
Analysis of VH genes in follicular and diffuse lymphoma shows ongoing somatic mutation and multiple isotype transcripts in early disease with changes during disease progression.
Blood - 1 Jun 1998
Ottensmeier C H, Thompsett A R, Zhu D, Wilkins B S, Sweetenham J W, Stevenson F K
Abstract excerpt
Investigations of VH gene mutational patterns in B-cell tumors are often performed at an arbitrary time point of disease. To assess the effects of disease progression, tumor-derived VH genes have been monitored from presentation through treatment and relapse in one patient with follicle center ly...
Topics
- Amino Acid Sequence
- Base Sequence
- Biopsy
- Disease Progression
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Isotypes
- Immunoglobulin Variable Region
- Immunophenotyping
- Lymphoma, B-Cell
- Lymphoma, Follicular
- Lymphoma, Large B-Cell, Diffuse
- Molecular Sequence Data
- Mutation
- Transcription, Genetic