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Article

Immunoglobulin VH somatic hypermutation in mantle cell lymphoma: mutated genotype correlates with better clinical outcome.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2006

Lai Raymond, Lefresne Shilo V, Franko Bevin, Hui David, Mirza Imran, Mansoor Adnan, Amin Hesham M, Ma Yupo

Abstract excerpt

Mantle cell lymphoma is an aggressive B-cell lymphoma for which the biology is incompletely understood. Previous studies have reported that somatic hypermutation of the variable region of the immunoglobulin heavy chain gene (V(H)), as commonly defined as <98% homology, can be detected in approximately one-third of mantle cell lymphoma, although the V(H) mutation status has not been found to significantly...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin Heavy Chain

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Share to Lymphoma, Mantle-Cell

Share to Sequence Homology, Nucleic Acid

Share to Somatic Hypermutation, Immunoglobulin

Source

Identifiers

PMID: 16980950
DOI: 10.1038/modpathol.3800677

Genes

IGH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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