Article
Conserved regulatory mechanisms of tyrosinase genes in mice and humans.
Pigment cell research - 1 Nov 1992
Tanaka M, Tanaka S, Miura H, Yamamoto H, Kikuchi H, Takeuchi T
Abstract excerpt
In vertebrates, melanin production is restricted to pigment cells. This cell type-specific melanogenesis is considered to involve cell type-specific expression of the tyrosinase gene. Recently, there have been several reports that sequences in the 5' flanking region of the mouse tyrosinase gene are responsible for cell type-specific expression of the transgene in mice. As the first step in the study of the...
Topics
- Animals
- Base Sequence
- Blotting, Southern
- DNA
- Female
- Gene Expression Regulation, Enzymologic
- Humans
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Monophenol Monooxygenase