Article
Expression of tyrosinase gene in transgenic albino mice: the heritable patterned coat colors.
Pigment cell research - 1 Nov 1992
Tanaka S, Takeuchi T
Abstract excerpt
To elucidate the regulatory mechanism for tyrosinase gene expression in vivo, we microinjected a mouse tyrosinase minigene, mg-Tyrs-J, into the fertilized eggs of BALB/c albino mice. As a result, we obtained six pigmented founder mice that exhibited non-standard coat color variations as well as the wild-type phenotype. These founder mice were subsequently crossed with BALB/c albino mice to establish the...
Topics
- Albinism
- Animals
- Base Sequence
- DNA
- Eye Color
- Gene Expression Regulation, Enzymologic
- Hair Color
- Mice
- Mice, Inbred BALB C
- Mice, Transgenic
- Molecular Sequence Data
- Monophenol Monooxygenase