New animal models to study the role of tyrosinase in normal retinal development.

Abstract excerpt

Albino animals display a hypopigmented phenotype associated with several visual abnormalities, including rod photoreceptor cell deficits, abnormal patterns of connections between the eye and the brain and a general underdevelopment of central retina. Oculocutaneous albinism type I, a common form of albinism, is caused by mutations in the tyrosinase gene. In mice, the albino phenotype can be corrected by...

Topics

• Albinism
• Albinism, Oculocutaneous
• Animals
• Chromosomes, Artificial, Bacterial
• Chromosomes, Artificial, Yeast
• Crosses, Genetic