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Article

Molecular characterization of the mouse tyrosinase gene: pigment cell-specific expression in transgenic mice.

Pigment cell research - 1 Nov 1992

Beermann F, Schmid E, Ganss R, Schütz G, Ruppert S

Abstract excerpt

Tyrosinase is the key enzyme in melanin synthesis, and is expressed in the pigment epithelium of the retina, a cell layer derived from the optic cup; and in neural crest-derived melanocytes of skin, hair follicle, choroid, and iris. The tyrosinase gene has been cloned and shown to map to the well-characterized c-locus (albino locus) of the mouse. Subsequent studies demonstrated that a functional tyrosinase...

Topics

Albinism
Animals
Choroid
Exons
Gene Expression
Gene Expression Regulation, Enzymologic
Hair
Iris
Melanocytes
Mice
Mice, Transgenic
Monophenol Monooxygenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phenotype

Pigment Epithelium of Eye

Promoter Regions, Genetic

Skin

Source

Identifiers

PMID: 1292012
DOI: 10.1111/j.1600-0749.1992.tb00552.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1292012-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Molecular characterization of the mouse tyrosinase gene: pigment cell-specific expression in transgenic mice.PMID 1292012Read ↗

Rescue of the albino phenotype by introduction of a functional tyrosinase gene into mice.Semantic proximity Read ↗

New animal models to study the role of tyrosinase in normal retinal development.Semantic proximity Read ↗

The structure and function of the mouse tyrosinase locus.Semantic proximity Read ↗

Distinct distal regulatory elements control tyrosinase expression in melanocytes and the retinal pigment epithelium.Semantic proximity Read ↗

Variegated expression and delayed retinal pigmentation during development in transgenic mice with a deletion in the locus control region of the tyrosinase gene.Semantic proximity Read ↗

Conserved regulatory mechanisms of tyrosinase genes in mice and humans.Semantic proximity Read ↗

The Tyr (albino) locus of the laboratory mouse.Semantic proximity Read ↗

Rescue of the albino phenotype by introducing a functional tyrosinase minigene into Kunming albino mice.Semantic proximity Read ↗

A distal tyrosinase upstream element stimulates gene expression in neural-crest-derived melanocytes of transgenic mice: position-independent and mosaic expression.Semantic proximity Read ↗

The tyrosinase gene and oculocutaneous albinism type 1 (OCA1): A model for understanding the molecular biology of melanin formation.Semantic proximity Read ↗

Increased transgene expression by the mouse tyrosinase enhancer is restricted to neural crest-derived pigment cells.Semantic proximity Read ↗

Molecular basis of dark-eyed albinism in the mouse.Semantic proximity Read ↗

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