A distal tyrosinase upstream element stimulates gene expression in neural-crest-derived melanocytes of transgenic mice: position-independent and mosaic expression.

doi:10.1242/dev.120.8.2103

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Article

A distal tyrosinase upstream element stimulates gene expression in neural-crest-derived melanocytes of transgenic mice: position-independent and mosaic expression.

Development (Cambridge, England) - 1 Aug 1994

Porter S D, Meyer C J

Abstract excerpt

We have assessed the importance of a melanocyte-specific DNase I hypersensitive site and matrix attachment region situated 15 kb upstream of the mouse tyrosinase gene by analysis in transgenic mice. Transgenes containing all, part, or none of this region linked to the tyrosinase promoter and huma...

Topics

Animals
Blotting, Northern
Gene Expression
Humans
Melanocytes
Mice
Mice, Transgenic
Monophenol Monooxygenase
Neural Crest
Ocular Physiological Phenomena
Phenotype
Pigmentation

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