Disorders of the inhibitory glycine receptor: the spastic mouse.

Abstract excerpt

The mutant mouse spastic suffers from a motor disorder of autosomal recessive inheritance which is characterized by tremor, myoclonic episodes, and a disturbed righting response. The most prominent alteration in the mutant is a substantial deficit of postsynaptic glycine receptor channels resulting in a dramatic reduction of glycinergic synaptic inhibition. Function and structure of the glycine receptor protein...

Topics

• Animals
• Disease Models, Animal
• Glycine
• Humans
• Mice
• Mice, Neurologic Mutants
• Movement Disorders
• Mutation
• Myoclonus
• Phenotype
• Receptors, GABA-A
• Receptors, Glycine