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<i>Grin2a</i> Ablation Distinctly Reshapes PV+ and SST+ Interneuron circuits in the Medial Prefrontal Cortex to Amplify Gamma Oscillations

2024-12-23

Abstract excerpt

Schizophrenia (SCZ) is a debilitating mental health disorder marked by cognitive deficits, especially in executive functions, which are often resistant to treatment. The GRIN2A gene encodes the GluN2A subunit of N-methyl-D-aspartate (NMDA) receptor. Rare coding mutations in GRIN2A , such as protein-truncating variants, increase susceptibility to SCZ by ∼20-fold. However, the effects on network dynamics and the f...

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Literature Corpus work
c967b9cb-4fd5-5b16-99e0-5f3ec5463b08
DOI
10.1101/2024.12.23.629830
Open publication

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<i>Grin2a</i> Ablation Distinctly Reshapes PV+ and SST+ Interneuron circuits in the Medial Prefrontal Cortex to Amplify Gamma OscillationsDOI 10.1101/2024.12.23.629830
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