Distinct physiological mechanisms underlie altered glycinergic synaptic transmission in the murine mutants spastic, spasmodic, and oscillator.

doi:10.1523/JNEUROSCI.3991-05.2006

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Article

Distinct physiological mechanisms underlie altered glycinergic synaptic transmission in the murine mutants spastic, spasmodic, and oscillator.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 May 2006

Graham Brett A, Schofield Peter R, Sah Pankaj, Margrie Troy W, Callister Robert J

Abstract excerpt

Spastic (spa), spasmodic (spd), and oscillator (ot) mice have naturally occurring glycine receptor (GlyR) mutations, which manifest as motor deficits and an exaggerated "startle response." Using whole-cell recording in hypoglossal motoneurons, we compared the physiological mechanisms by which each mutation alters GlyR function. Mean glycinergic miniature IPSC (mIPSC) amplitude and frequency were dramatically...

Topics

6-Cyano-7-nitroquinoxaline-2,3-dione
Analysis of Variance
Animals
Biological Clocks
Brain Stem
Dose-Response Relationship, Radiation
Drug Interactions
Electric Stimulation
Excitatory Amino Acid Antagonists

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

GABA Antagonists

Genotype

Glycine

Glycine Agents

In Vitro Techniques

Male

Membrane Potentials

Mice

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Identifiers

PMID: 16672662
DOI: 10.1523/JNEUROSCI.3991-05.2006
PMCID: PMC6674148

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