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Article

Distinct physiological mechanisms underlie altered glycinergic synaptic transmission in the murine mutants spastic, spasmodic, and oscillator.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 May 2006

Graham Brett A, Schofield Peter R, Sah Pankaj, Margrie Troy W, Callister Robert J

Abstract excerpt

Spastic (spa), spasmodic (spd), and oscillator (ot) mice have naturally occurring glycine receptor (GlyR) mutations, which manifest as motor deficits and an exaggerated "startle response." Using whole-cell recording in hypoglossal motoneurons, we compared the physiological mechanisms by which each mutation alters GlyR function. Mean glycinergic miniature IPSC (mIPSC) amplitude and frequency were dramatically...

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Identifiers

PMID: 16672662
DOI: 10.1523/JNEUROSCI.3991-05.2006
PMCID: PMC6674148

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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