Article
A phospho-deficient α3 glycine receptor mutation alters synaptic glycine and GABA release in mouse spinal dorsal horn neurons.
The Journal of physiology - 1 Sept 2023
Werynska Karolina, Neumann Elena, Cramer Teresa, Ganley Robert P, Gingras Jacinthe, Zeilhofer Hanns Ulrich
Abstract excerpt
Glycine receptors (GlyRs), together with GABAA receptors, mediate postsynaptic inhibition in most spinal cord and hindbrain neurons. In several CNS regions, GlyRs are also expressed in presynaptic terminals. Here, we analysed the effects of a phospho-deficient mutation (S346A) in GlyR α3 subunits on inhibitory synaptic transmission in superficial spinal dorsal horn neurons, where this subunit is abundantly...
Topics
- Animals
- Mice
- gamma-Aminobutyric Acid
- Glycine
- Mutation
- Posterior Horn Cells
- Receptors, GABA-A
- Receptors, Glycine
- Synaptic Transmission