Article
Glycine receptor knock-in mice and hyperekplexia-like phenotypes: comparisons with the null mutant.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Sept 2003
Findlay Geoffrey S, Phelan Rachel, Roberts Michael T, Homanics Gregg E, Bergeson Susan E, Lopreato Gregory F, Mihic S John, Blednov Yuri A, Harris R Adron
Abstract excerpt
Strychnine-sensitive glycine receptors (GlyRs) inhibit neurotransmission in the spinal cord and brainstem. To better define the function of this receptor in vivo, we constructed a point mutation that impairs receptor function in the alpha1-subunit and compared these knock-in mice to oscillator (spdot) mice lacking functional GlyR alpha1-subunits. Mutation of the serine residue at amino acid 267 to glutamine...
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