Article

Shank2 expression identifies a subpopulation of glycinergic interneurons involved in nociception and altered in an autism mouse model

2020-05-25

Abstract excerpt

Patients suffering from Autism Spectrum Disorders (ASD) experience disturbed nociception in form of either hyposensitivity to pain or hypersensitivity and allodynia. We have determined that Shank2-KO mice, which recapitulate the genetic and behavioural disturbances of ASD, display increased sensitivity to formalin pain and thermal, but not mechanical allodynia. We demonstrate that high levels of Shank2 expression...

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Literature Corpus work: 7bd0c0cb-b65e-5dfc-ae7e-0f8b7c60bed3
DOI: 10.1101/2020.05.24.112052

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