Article
Genetic ablation of GINIP-expressing primary sensory neurons strongly impairs Formalin-evoked pain.
Scientific reports - 27 Feb 2017
Urien Louise, Gaillard Stéphane, Lo Re Laure, Malapert Pascale, Bohic Manon, Reynders Ana, Moqrich Aziz
Abstract excerpt
Primary sensory neurons are heterogeneous by myriad of molecular criteria. However, the functional significance of this remarkable heterogeneity is just emerging. We precedently described the GINIP+ neurons as a new subpopulation of non peptidergic C-fibers encompassing the free nerve ending cutaneous MRGPRD+ neurons and C-LTMRs. Using our recently generated ginip mouse model, we have been able to selectively...
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