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Article

Helical alpha-synuclein forms highly conductive ion channels.

Biochemistry - 18 Dec 2007

Zakharov Stanislav D, Hulleman John D, Dutseva Elena A, Antonenko Yuri N, Rochet Jean-Christophe, Cramer William A

Abstract excerpt

Alpha-synuclein (alphaS) is a cytosolic protein involved in the etiology of Parkinson's disease (PD). Disordered in an aqueous environment, alphaS develops a highly helical conformation when bound to membranes having a negatively charged surface and a large curvature. It exhibits a membrane-permeabilizing activity that has been attributed to oligomeric protofibrillar forms. In this study, monomeric wild-type...

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Identifiers

PMID: 18031063
DOI: 10.1021/bi701275p

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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