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Article

The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6.

The Journal of biological chemistry - 27 Dec 2013

Mercer Robert C C, Ma Li, Watts Joel C, Strome Robert, Wohlgemuth Serene, Yang Jing, Cashman Neil R, Coulthart Michael B, Schmitt-Ulms Gerold, Jhamandas Jack H, Westaway David

Abstract excerpt

Widely expressed in the adult central nervous system, the cellular prion protein (PrP(C)) is implicated in a variety of processes, including neuronal excitability. Dipeptidyl aminopeptidase-like protein 6 (DPP6) was first identified as a PrP(C) interactor using in vivo formaldehyde cross-linking of wild type (WT) mouse brain. This finding was confirmed in three cell lines and, because DPP6 directs the functional...

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Identifiers

PMID: 24225951
DOI: 10.1074/jbc.M113.488650
PMCID: PMC3873577

Genes

DPP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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