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Review: PrP 106‐126 – 25 years after

12 Jan 2019

Abstract excerpt

A quarter of a century ago, we proposed an innovative approach to study the pathogenesis of prion disease, one of the most intriguing biomedical problems that remains unresolved. The synthesis of a peptide homologous to residues 106-126 of the human prion protein (PrP106-126), a sequence present in the PrP amyloid protein of Gerstmann-Sträussler-Scheinker syndrome patients, provided a tractable tool for...

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PMID: 30635947
DOI: 10.1111/nan.12538

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