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Article

Altered toxicity of the prion protein peptide PrP106-126 carrying the Ala(117)-->Val mutation.

The Biochemical journal - 15 Mar 2000

Brown D R

Abstract excerpt

The inherited prion diseases such as Gerstmann-Sträussler-Scheinker syndrome (GSS) are linked to point mutations in the gene coding for the cellular isoform of the prion protein (PrP(C)). One particular point mutation A117V (Ala(117)-->Val) is linked to a variable pathology that usually includes...

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Identifiers

PMID: 10698707
PMCID: PMC1220913

Genes

GSS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10698707-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Altered toxicity of the prion protein peptide PrP106-126 carrying the Ala(117)-->Val mutation.PMID 10698707Read ↗

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Neurofibrillary tangles in Gerstmann-Sträussler-Scheinker syndrome with the A117V prion gene mutation.Semantic proximity Read ↗

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