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Article

A Redox-Active Fluorescent pH Indicator for Detecting Plasmodium falciparum Strains with Reduced Responsiveness to Quinoline Antimalarial Drugs.

ACS infectious diseases - 10 Feb 2017

Jida Mouhamad, Sanchez Cecilia P, Urgin Karène, Ehrhardt Katharina, Mounien Saravanan, Geyer Aurelia, Elhabiri Mourad, Lanzer Michael, Davioud-Charvet Elisabeth

Abstract excerpt

Mutational changes in the Plasmodium falciparum chloroquine resistance transporter (PfCRT) have been associated with differential responses to a wide spectrum of biologically active compounds including current and former quinoline and quinoline-like antimalarial drugs. PfCRT confers altered drug responsiveness by acting as a transport system, expelling drugs from the parasite's digestive vacuole where these drugs...

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PMID: 28183182
DOI: 10.1021/acsinfecdis.5b00141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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