Article
Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities.
Scientific reports - 30 Sept 2015
Pulcini Serena, Staines Henry M, Lee Andrew H, Shafik Sarah H, Bouyer Guillaume, Moore Catherine M, Daley Daniel A, Hoke Matthew J, Altenhofen Lindsey M, Painter Heather J, Mu Jianbing, Ferguson David J P, Llinás Manuel, Martin Rowena E, Fidock David A, Cooper Roland A, Krishna Sanjeev
Abstract excerpt
Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, are the major determinant of chloroquine resistance in this lethal human malaria parasite. Here, we describe P. falciparum lines subjected to selection by amantadine or blasticidin that carry PfCRT mutations (C101F or L272F), causing the development of enlarged food vacuoles. These parasites also have increased sensitivity to...
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