Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Growth retardation as well as spleen and thymus involution in latent TGF-beta binding protein (Ltbp)-3 null mice.

Journal of cellular physiology - 1 Aug 2003

Chen Yan, Dabovic Branka, Colarossi Cristina, Santori Fabio R, Lilic Mirjana, Vukmanovic Stanislav, Rifkin Daniel B

Abstract excerpt

The latent TGF-beta binding protein (LTBP)-3 is an extracellular matrix (ECM) protein that binds the small latent complex (SLC) of TGF-beta. Disruption of the Ltbp-3 gene by homologous recombination in mice yields mutant animals that display multiple skeletal abnormalities. In addition, these mice have retarded growth. On an inbred 129 SvEv background, half of the Ltbp-3 mutant mice die between 3 and 4 weeks...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Congenital Abnormalities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Corticosterone

Share to Growth Disorders

Share to Injections, Intravenous

Share to Latent TGF-beta Binding Proteins

Share to Spleen

Share to Thymus Gland

Source

Identifiers

PMID: 12811825
DOI: 10.1002/jcp.10296

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Growth retardation as well as spleen and thymus involution in latent TGF-beta binding protein (Ltbp)-3 null mice.PMID 12811825Read ↗

Osteopetrosis-like phenotype in latent TGF-beta binding protein 3 deficient mice.Semantic proximity Read ↗

Bone defects in latent TGF-beta binding protein (Ltbp)-3 null mice; a role for Ltbp in TGF-beta presentationSemantic proximity Read ↗

Control of lung development by latent TGF-β binding proteins.Semantic proximity Read ↗

Disruption of the latent transforming growth factor-beta binding protein-1 gene causes alteration in facial structure and influences TGF-beta bioavailability.Semantic proximity Read ↗

Expression of truncated latent TGF-beta-binding protein modulates TGF-beta signaling.Semantic proximity Read ↗

Transforming Growth Factor-β3 (TGF-β3) Knock-in Ameliorates Inflammation Due to TGF-β1 Deficiency While Promoting Glucose ToleranceSemantic proximity Read ↗

Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction.Semantic proximity Read ↗

Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer.Semantic proximity Read ↗

Generation of mice with a conditional allele for the transforming growth factor beta3 gene.Semantic proximity Read ↗

Interaction of insulin-like growth factor binding protein-3 with latent transforming growth factor-beta binding protein-1.Semantic proximity Read ↗

Transforming growth factor beta (TGFbeta1, TGFbeta2 and TGFbeta3) null-mutant phenotypes in embryonic gonadal development.Semantic proximity Read ↗

The skeletal phenotypes of TRalpha and TRbeta mutant mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.