Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bone defects in latent TGF-beta binding protein (Ltbp)-3 null mice; a role for Ltbp in TGF-beta presentation

1 Oct 2002

Abstract excerpt

The latent transforming growth factor (TGF)-beta binding proteins (LTBP)-1, -3 and -4 bind the latent form of the multipotent cytokine TGF-beta. To examine the function of the LTBPs, we made a null mutation of Ltbp-3 by gene targeting. The homozygous mutant animals developed cranio-facial malformations by 12 days. By three months, there was a pronounced rounding of the cranial vault, extension of the mandible...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Dental Protein Studies
Share to Bone Metabolism and Diseases
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12379497
DOI: 10.1677/joe.0.1750129

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bone defects in latent TGF-beta binding protein (Ltbp)-3 null mice; a role for Ltbp in TGF-beta presentationPMID 12379497Read ↗

Osteopetrosis-like phenotype in latent TGF-beta binding protein 3 deficient mice.Semantic proximity Read ↗

Disruption of the latent transforming growth factor-beta binding protein-1 gene causes alteration in facial structure and influences TGF-beta bioavailability.Semantic proximity Read ↗

Growth retardation as well as spleen and thymus involution in latent TGF-beta binding protein (Ltbp)-3 null mice.Semantic proximity Read ↗

Systematic analysis of palatal transcriptome to identify cleft palate genes within TGFβ3-knockout mice alleles: RNA-Seq analysis of TGFβ3 Mice.Semantic proximity Read ↗

Overexpression of BMP3 in the developing skeleton alters endochondral bone formation resulting in spontaneous rib fracturesSemantic proximity Read ↗

TIEG-null mice display an osteopenic gender-specific phenotype.Semantic proximity Read ↗

Wnt/beta-catenin signaling regulates cranial base development and growth.Semantic proximity Read ↗

Tgfb1 expressed in the Tgfb3 locus partially rescues the cleft palate phenotype of Tgfb3 null mutants.Semantic proximity Read ↗

Enamel and dental anomalies in latent-transforming growth factor beta-binding protein 3 mutant mice.Semantic proximity Read ↗

Control of lung development by latent TGF-β binding proteins.Semantic proximity Read ↗

Pathogenesis of cleft palate in TGF-beta3 knockout mice.Semantic proximity Read ↗

Unique and redundant roles of Smad3 in TGF-beta-mediated regulation of long bone development in organ culture.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.