Article
Osteopetrosis-like phenotype in latent TGF-beta binding protein 3 deficient mice.
Bone - 1 Jul 2005
Dabovic B, Levasseur R, Zambuto L, Chen Y, Karsenty G, Rifkin D B
Abstract excerpt
LTBPs are extracellular matrix proteins resembling fibrillins. LTBP-1, 3, and 4 covalently bind latent TGF-beta and modulate tissue levels of this potent cytokine through regulation of its secretion, localization, and/or activation. To address LTBP function in vivo, we generated Ltbp-3 null mice. Ltbp-3-/- animals developed craniofacial abnormalities due to early ossification of the skull base synchondroses and...
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