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Transforming Growth Factor-β3 (TGF-β3) Knock-in Ameliorates Inflammation Due to TGF-β1 Deficiency While Promoting Glucose Tolerance

21 Sept 2013

Abstract excerpt

Three homologues of TGF-β exist in mammals as follows: TGF-β1, TGF-β2, and TGF-β3. All three proteins share high homology in their amino acid sequence, yet each TGF-β isoform has unique heterologous motifs that are highly conserved during evolution. Although these TGF-β proteins share similar properties in vitro , isoform-specific properties have been suggested through in vivo studies and by the unique phenotypes...

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PMID: 24056369
DOI: 10.1074/jbc.m113.480764

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